Dysplastic nevus - I-Dysplastic Nevus
☆ Emiphumeleni ka-2022 ye-Stiftung Warentest evela eJalimane, ukwaneliseka kwabathengi nge-ModelDerm bekungaphansi kancane kunokuxhumana okukhokhelwayo kwe-telemedicine.
Dysplastic nevi ― Biopsy inconyelwe abantu baseNtshonalanga.
References
I- Dysplastic nevus , eyaziwa nangokuthi i-atypical noma i-Clarks nevus, ibangele izimpikiswano ku-dermatology kanye ne-dermatopathology. Odokotela bavame ukuhlola lezi zimvukuzane ngoba zingabukeka zingajwayelekile futhi ziphakamise ukukhathazeka ngemelanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi , eyaziwa nangokuthi i-atypical noma i-Clark nevi, ngezinye izikhathi ingaholela ku-melanoma. Cishe ama-36% e-melanoma atholakala eduze ne-dysplastic nevi. Izimpawu zokuthi i-dysplastic nevus ingase iphenduke ibe yi-melanoma zihlanganisa ukuma okungalingani, izinguquko ze-pigment eyengeziwe, noma umbala ompunga. Le midlavuza ivamise ukwenzeka besebancane (maphakathi neminyaka engamashumi amathathu) , ingaba miningi, futhi iba sesiqu. Ngokofuzo, dysplastic nevi iphakathi kwe-benign nevi ne-melanoma. Nokho, u-20% kuya ku-30% kuphela wama-melanoma avela ku-nevi ekhona. Njengoba i-nevi eminingi ingabi yi-melanoma, ngokuvamile akunconywa ukuyisusa ngokuvimbela.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
I-melanoma wuhlobo lwesimila olwakha lapho ama-melanocyte, amangqamuzana abhekele umbala wesikhumba, eba nomdlavuza. Ama-melanocyte avela ku-neural crest. Lokhu kusho ukuthi i-melanoma ingakwazi ukukhula hhayi esikhumbeni kuphela kodwa nakwezinye izindawo lapho amangqamuzana e-neural crest efuduka khona, njengepheshana lamathumbu nobuchopho. Izinga lokusinda kweziguli ezine-melanoma yesigaba sokuqala (isigaba 0) liphezulu ku-97%, kuyilapho lehla kakhulu lifinyelele cishe ku-10% kulabo abatholakala benesifo esisezingeni eliphezulu (isigaba IV) .
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Cancer risk
Njengoba kubonakala kubantu baseCaucasia e-United States, labo abane-dysplastic nevi basengozini yokuphila yonke yokuba ne-melanoma engaphezu kuka-10%. Ngakolunye uhlangothi, labo abangenayo i-dysplastic nevus basengozini yokuba ne-melanoma engaphansi kuka-1%.
○ Precaution kubantu abane-dysplastic nevi
Ukuzihlola kwesikhumba ngokuvamile kuyanconywa ukuze kuvinjwe i-melanoma (ngokuhlonza i-atypical nevi engasuswa) noma ukuze kutholwe izimila ezikhona kusenesikhathi. Abantu abanomlando womuntu siqu noma womndeni onomdlavuza wesikhumba noma abane-atypical nevi eminingi kufanele babonane nodokotela wesikhumba okungenani kanye ngonyaka ukuze baqiniseke ukuthi abayitholi i-melanoma.
Isifinyezo esithi [ABCDE] sibe usizo ekusizeni abahlinzeki bezempilo kanye nabantu abavamile bakhumbule izici ezibalulekile ze-melanoma. Ngeshwa kumuntu ojwayelekile, ama-seborrheic keratoses amaningi, amanye ama-lentigo senilis, ngisho nezinsumpa zingase zibe nezici ze-[ABCDE], futhi azikwazi ukuhlukaniswa nemelanoma.
○ [ABCDE]
Asymmetrical: Isilonda sesikhumba esi-asymmetrical.
Border: Umngcele wesilonda awujwayelekile.
Color: I-melanoma ivamise ukuba nemibala eminingi engajwayelekile.
Diameter: I-nevi enkulu kuno-6 mm maningi amathuba okuba i-melanoma kune-nevi encane.
Evolution: Ukuvela (okungukuthi, ushintsho) kwe-nevus noma isilonda kungase kubonise ukuthi isilonda siba sibi.